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Phenylephrine And Ketorolac · Omidria

Small molecule · Antagonist of alpha-1 adrenergic receptor (ADRA1A), cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2) · developed by Rayner Surgical

Approved FDA, May 2014

1 Registered trials

What is Phenylephrine And Ketorolac?

Omidria is a combination of phenylephrine and ketorolac added to ocular irrigating solution during cataract surgery. Phenylephrine is an alpha-1 adrenergic agonist that contracts the iris radial muscle to maintain pupil size. Ketorolac inhibits COX-1 and COX-2 to reduce prostaglandin synthesis, preventing surgically induced miosis and postoperative pain.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: Omidria
Drug type: Small molecule
Targets: alpha-1 adrenergic receptor (ADRA1A), cyclooxygenase-1 (PTGS1), cyclooxygenase-2 (PTGS2)
Mechanism: Antagonist of alpha-1 adrenergic receptor (ADRA1A), cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2)
Pathways: prostaglandin synthesis inhibition
Therapy area: Ophthalmology
Developer: Rayner Surgical
In trials of: OMER
FDA status: Approved as Omidria (May 30, 2014), NDA205388 · FDA label

✅ FDA-approved uses

Maintaining pupil size by preventing intraoperative miosis
Reducing postoperative ocular pain

From the indications section of the FDA label (version of Apr 8, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT03864133	Phase 4	Cataract	Completed	OMER

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Cataract

Other drugs acting on ADRA1A / PTGS1 / PTGS2

AXS-07 FDA approved Diclofenac FDA approved Epinephrine FDA approved Ibuprofen FDA approved Ketorolac FDA approved OMS302 FDA approved OMS302-PE FDA approved Phenylephrine FDA approved STP707 Phase 1

Sources

Updated Oct 3, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z