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Ketorolac · Ketorolac Tromethamine

Small molecule · Inhibitor of cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2) · developed by Abbvie

Approved FDA, May 2003

2 Registered trials

What is Ketorolac?

Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug that non-selectively inhibits cyclooxygenase-1 and cyclooxygenase-2, reducing prostaglandin biosynthesis. It has analgesic, anti-inflammatory, and antipyretic activity.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: Ketorolac Tromethamine
Drug type: Small molecule
Targets: cyclooxygenase-1 (PTGS1), cyclooxygenase-2 (PTGS2)
Mechanism: Inhibitor of cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2)
Pathways: prostaglandin biosynthesis
Therapy area: Ophthalmology
Developer: Abbvie
In trials of: CPIX
FDA status: Approved as Ketorolac Tromethamine (May 30, 2003), NDA021528 · FDA label
UNII: YZI5105V0L

✅ FDA-approved uses

Reduction of ocular pain and burning/stinging following corneal refractive surgery

From the indications section of the FDA label (version of Jun 10, 2024). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT01901393	Phase 4	Pain	Completed	CPIX
NCT01650519	Phase 4	Arthroscopic Knee Surgery	Completed	CPIX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Arthroscopic Knee SurgeryPain

Other drugs acting on PTGS1 / PTGS2

AXS-07 FDA approved Diclofenac FDA approved Ibuprofen FDA approved OMS302 FDA approved OMS302-PE FDA approved Phenylephrine And Ketorolac FDA approved STP707 Phase 1

Sources

Updated Oct 3, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z