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OMS302 · Ketorolac Tromethamine, Omidria

Small molecule · Inhibitor of alpha-1 adrenergic receptor (ADRA1A), cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2) · developed by Rayner Surgical

Approved FDA, May 2014
3 Registered trials

What is OMS302?

OMS302 is a combination of phenylephrine and ketorolac added to ocular irrigating solution during cataract surgery or intraocular lens replacement. Phenylephrine acts as an alpha-1 adrenergic agonist to maintain pupil size, while ketorolac inhibits cyclooxygenase enzymes to reduce postoperative pain and prevent surgically induced miosis.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
Ketorolac Tromethamine, Omidria
Drug type
Small molecule
Targets
alpha-1 adrenergic receptor (ADRA1A), cyclooxygenase-1 (PTGS1), cyclooxygenase-2 (PTGS2)
Mechanism
Inhibitor of alpha-1 adrenergic receptor (ADRA1A), cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2)
Pathways
prostaglandin synthesis
Therapy area
Ophthalmology
Developer
Rayner Surgical
In trials of
OMER
FDA status
Approved as Ketorolac Tromethamine, Omidria (May 30, 2014), NDA205388 · FDA label

✅ FDA-approved uses

From the indications section of the FDA label (version of Apr 8, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT02132312 Phase 3 Unilateral Cataract Extraction Completed OMER
NCT02093689 Phase 3 Intraocular Lens Replacement Terminated OMER
NCT01193127 Phase 2 Cataract Completed OMER

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

CataractCongenital CataractIntraocular Lens ReplacementIntraoperative Floppy Iris SyndromeUnilateral Cataract Extraction

Other drugs acting on ADRA1A / PTGS1 / PTGS2

AXS-07 FDA approved Diclofenac FDA approved Epinephrine FDA approved Ibuprofen FDA approved Ketorolac FDA approved OMS302-PE FDA approved Phenylephrine FDA approved Phenylephrine And Ketorolac FDA approved STP707 Phase 1

Sources

Updated Oct 3, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.