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Diclofenac · Cataflam, Diclofenac Potassium

Small molecule · Inhibitor of cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2) · developed by Novartis

Approved FDA, Nov 1993

1 Registered trials

What is Diclofenac?

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2), blocking prostaglandin synthesis.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: Cataflam, Diclofenac Potassium, Zipsor, ZORVOLEX
Drug type: Small molecule
Targets: cyclooxygenase-1 (PTGS1), cyclooxygenase-2 (PTGS2)
Mechanism: Inhibitor of cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2)
Pathways: prostaglandin synthesis, arachidonic acid metabolism
Therapy area: Musculoskeletal
Developer: Novartis
In trials of: TEVA
FDA status: Approved as Cataflam, Diclofenac Potassium, Zipsor (November 24, 1993), NDA020142 · FDA label

✅ FDA-approved uses

Mild to moderate acute pain (Zipsor)
Mild to moderate acute pain (Diclofenac Potassium)

From the indications section of the FDA label (version of Sep 3, 2025). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT03949673	Phase 2	Osteoarthritis, Knee	Terminated	TEVA

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Osteoarthritis, HipOsteoarthritis, Knee

Other drugs acting on PTGS1 / PTGS2

AXS-07 FDA approved Ibuprofen FDA approved Ketorolac FDA approved OMS302 FDA approved OMS302-PE FDA approved Phenylephrine And Ketorolac FDA approved STP707 Phase 1

Sources

Updated Oct 3, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z