Phenylephrine · Phenylephrine Hci, Phenylephrine Hydrochloride

What is Phenylephrine?

Phenylephrine is an alpha-1 adrenergic receptor agonist that causes vasoconstriction and increases blood pressure.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Phenylephrine Hci, Phenylephrine Hydrochloride, Vazculep

Drug type

Small molecule

Targets

alpha-1 adrenergic receptor (ADRA1A)

Mechanism

Agonist of alpha-1 adrenergic receptor (ADRA1A)

Pathways

vasoconstriction

Therapy area

Ophthalmology

Developer

Hikma

In trials of

BLRX, OMER

FDA status

Approved as Phenylephrine Hci, Phenylephrine Hydrochloride, Vazculep (December 20, 2012), NDA203826 · FDA label

✅ FDA-approved uses

• Hypotension in septic shock or anesthesia (Phenylephrine Hydrochloride)

From the indications section of the FDA label (version of Dec 26, 2024). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Acute PainCongenital CataractPain ReductionUnilateral Cataract Extraction

Other drugs acting on ADRA1A

Sources

• FDA label (DailyMed)
• FDA label Phenylephrine Hydrochloride (2024-12-26), indications
• FDA label Phenylephrine Hci (2024-02-22), indications
• NCI Thesaurus
• ClinicalTrials.gov NCT04829799

Updated Oct 3, 2026.