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Ibuprofen · Children'S Advil, IB-100

Small molecule · Inhibitor of cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2) · developed by Haleon Us Holdings

Approved FDA, Sep 1989
4 Registered trials

What is Ibuprofen?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis. It has analgesic, anti-inflammatory, and antipyretic properties. Ibuprofen is used to treat pain and fever.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
Children'S Advil, IB-100, NSC-256857, Caldolor
Drug type
Small molecule
Targets
cyclooxygenase-1 (PTGS1), cyclooxygenase-2 (PTGS2)
Mechanism
Inhibitor of cyclooxygenase-1 (PTGS1) and cyclooxygenase-2 (PTGS2)
Pathways
prostaglandin synthesis
Therapy area
Musculoskeletal
Developer
Haleon Us Holdings
In trials of
CPIX
FDA status
Approved as Children'S Advil (September 19, 1989), NDA019833
UNII
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🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT02583399 Phase 4 Pain Completed CPIX
NCT01773005 Phase 4 Pain Completed CPIX
NCT01650519 Phase 4 Arthroscopic Knee Surgery Completed CPIX
NCT01334957 Phase 4 Pain Completed CPIX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Arthroscopic Knee SurgeryPain

Other drugs acting on PTGS1 / PTGS2

AXS-07 FDA approved Diclofenac FDA approved Ketorolac FDA approved OMS302 FDA approved OMS302-PE FDA approved Phenylephrine And Ketorolac FDA approved STP707 Phase 1

Sources

Updated Oct 3, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.