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STP707

Oligonucleotide (siRNA) · Gene silencing: transforming growth factor-beta 1 (TGFB1) and cyclo-oxygenase-2 (PTGS2) · developed by Sirnaomics

Phase 1 Most advanced trial (none active)
1 Registered trials

What is STP707?

STP707 is a polypeptide nanoparticle-based therapeutic containing two siRNAs targeting transforming growth factor-beta 1 (TGF-beta 1) and cyclo-oxygenase-2 (COX-2). It silences these genes to inhibit TGF-beta 1-mediated immunosuppression and COX-2-mediated signaling, potentially enhancing anti-tumor immunity and promoting cytotoxic T-lymphocyte responses against tumor cells.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type
Oligonucleotide (siRNA)
Targets
transforming growth factor-beta 1 (TGFB1), cyclo-oxygenase-2 (PTGS2)
Mechanism
Gene silencing: transforming growth factor-beta 1 (TGFB1) and cyclo-oxygenase-2 (PTGS2)
Pathways
TGF-beta signaling, apoptosis, angiogenesis
Therapy area
Immunology, Oncology
Developer
Sirnaomics
In trials of
MEDP
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT05309915 Phase 1 Healthy Subjects Completed MEDP

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Healthy Subjects

Other drugs acting on TGFB1 / PTGS2

AXS-07 FDA approved Diclofenac FDA approved Ibuprofen FDA approved Ketorolac FDA approved OMS302 FDA approved OMS302-PE FDA approved Phenylephrine And Ketorolac FDA approved Dalutrafusp Alfa Phase 2 Ficerafusp Alfa Phase 2/3 Linavonkibart Phase 1

Sources

Updated Oct 3, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.