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ARO-RAGE

Oligonucleotide (siRNA) · Gene silencing: RAGE (AGER) · developed by ARROWHEAD PHARMACEUTICALS

Phase 2 Most advanced trial

ARWR Developer

1 Registered trials

What is ARO-RAGE?

ARO-RAGE is an siRNA therapeutic that silences RAGE (receptor for advanced glycation end products) expression. It is administered by inhalation as a nebulized solution and is being studied in asthma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Oligonucleotide (siRNA)
Targets: RAGE (AGER)
Mechanism: Gene silencing: RAGE (AGER)
Therapy area: Respiratory
Developer: ARROWHEAD PHARMACEUTICALS (ARWR)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07241546	Phase 2	Asthma	Recruiting	ARWR

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Asthma

Other drugs acting on AGER

Azeliragon Phase 2

More from ARROWHEAD PHARMACEUTICALS

Plozasiran FDA approved ARC-521 Phase 1 ARC-AAT Phase 2 ARO-033 Phase 1 ARO-ALK7 Phase 1/2 ARO-ANG 3 Phase 2 ARO-APOC3 Phase 2 ARO-ATXN2 Phase 1 ARO-C3 Phase 1/2 ARO-CFB Phase 1 ARO-DIMERPA Phase 1/2 ARO-ENaC Phase 1/2

Sources

ClinicalTrials.gov NCT07241546

Updated Oct 3, 2026. Something wrong or missing? Report it on the ARWR page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z