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ARO-CFB

Oligonucleotide (siRNA) · developed by ARROWHEAD PHARMACEUTICALS

Phase 1 Most advanced trial (none active)

ARWR Developer

1 Registered trials

What is ARO-CFB?

ARO-CFB is an siRNA that silences complement factor B (CFB), reducing activation of the alternative complement pathway. It is being studied in IgA nephropathy, a kidney disease characterized by IgA immune complex deposition and complement-mediated inflammation.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Oligonucleotide (siRNA)
Therapy area: Immunology, Renal & urology
Developer: ARROWHEAD PHARMACEUTICALS (ARWR)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT06209177	Phase 1	IgA Nephropathy	Completed	ARWR

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

IgA Nephropathy

More from ARROWHEAD PHARMACEUTICALS

Plozasiran FDA approved ARC-521 Phase 1 ARC-AAT Phase 2 ARO-033 Phase 1 ARO-ALK7 Phase 1/2 ARO-ANG 3 Phase 2 ARO-APOC3 Phase 2 ARO-ATXN2 Phase 1 ARO-C3 Phase 1/2 ARO-DIMERPA Phase 1/2 ARO-ENaC Phase 1/2 ARO-HBV Phase 1/2

Follow ARWR, the company behind ARO-CFB

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z