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ARO-ANG 3

Oligonucleotide (siRNA) · Gene silencing · developed by ARROWHEAD PHARMACEUTICALS

Phase 2 Most advanced trial (none active)

ARWR Developer

2 Registered trials

What is ARO-ANG 3?

ARO-ANG3 is an siRNA therapeutic studied in mixed dyslipidemia and homozygous familial hypercholesterolemia.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: ARO-ANG3
Drug type: Oligonucleotide (siRNA)
Mechanism: Gene silencing
Therapy area: Metabolic
Developer: ARROWHEAD PHARMACEUTICALS (ARWR)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05217667	Phase 2	Homozygous Familial Hypercholesterolemia	Terminated	ARWR
NCT04832971	Phase 2	Mixed Dyslipidemia	Completed	ARWR

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Homozygous Familial HypercholesterolemiaMixed Dyslipidemia

More from ARROWHEAD PHARMACEUTICALS

Plozasiran FDA approved ARC-521 Phase 1 ARC-AAT Phase 2 ARO-033 Phase 1 ARO-ALK7 Phase 1/2 ARO-APOC3 Phase 2 ARO-ATXN2 Phase 1 ARO-C3 Phase 1/2 ARO-CFB Phase 1 ARO-DIMERPA Phase 1/2 ARO-ENaC Phase 1/2 ARO-HBV Phase 1/2

Sources

ClinicalTrials.gov NCT05217667

Updated Oct 3, 2026. Something wrong or missing? Report it on the ARWR page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z