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ARO-ENaC

Oligonucleotide (siRNA) · Gene silencing: epithelial sodium channel (ENaC) (SCNN1B) · developed by ARROWHEAD PHARMACEUTICALS

Phase 1/2 Most advanced trial (none active)

ARWR Developer

1 Registered trials

What is ARO-ENaC?

ARO-ENaC is a small interfering RNA (siRNA) that reduces epithelial sodium channel (ENaC) expression. It is administered by inhalation and is being studied in cystic fibrosis.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Oligonucleotide (siRNA)
Targets: epithelial sodium channel (ENaC) (SCNN1B)
Mechanism: Gene silencing: epithelial sodium channel (ENaC) (SCNN1B)
Therapy area: Respiratory
Developer: ARROWHEAD PHARMACEUTICALS (ARWR)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT04375514	Phase 1/2	Cystic Fibrosis, Pulmonary	Terminated	ARWR

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Cystic Fibrosis, Pulmonary

More from ARROWHEAD PHARMACEUTICALS

Plozasiran FDA approved ARC-521 Phase 1 ARC-AAT Phase 2 ARO-033 Phase 1 ARO-ALK7 Phase 1/2 ARO-ANG 3 Phase 2 ARO-APOC3 Phase 2 ARO-ATXN2 Phase 1 ARO-C3 Phase 1/2 ARO-CFB Phase 1 ARO-DIMERPA Phase 1/2 ARO-HBV Phase 1/2

Sources

ClinicalTrials.gov NCT04375514

Updated Oct 3, 2026. Something wrong or missing? Report it on the ARWR page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z