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VY-AADC02 · NBIB-1817

Gene therapy (AAV vector) · Gene replacement · developed by Neurocrine Biosciences

Phase 1 Most advanced trial (none active)

NBIX Developer

1 Registered trials

What is VY-AADC02?

VY-AADC02 is an adeno-associated viral vector serotype 2 carrying the human aromatic L-amino acid decarboxylase gene. It is administered by direct infusion into the brain to restore AADC enzyme activity. The drug is studied in Parkinson's disease.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: NBIB-1817
Drug type: Gene therapy (AAV vector)
Mechanism: Gene replacement
Therapy area: Neurology
Developer: Neurocrine Biosciences (NBIX)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1
UNII: 2WRS0PE04O

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT03562494	Phase 1	Parkinson's Disease	Completed	NBIX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Parkinson's Disease

More from Neurocrine Biosciences

Crinecerfont FDA approved Valbenazine FDA approved Chronocort Phase 3 DITEST Phase 1 Luvadaxistat Phase 2 NBI-1065845 Phase 3 NBI-1065890 Phase 2 NBI-1070770 Phase 2 NBI-1117567 Phase 2 NBI-1117568 Phase 3 NBI-1117570 Phase 2 NBI-827104 Phase 2

Sources

ClinicalTrials.gov NCT03562494

Updated Oct 3, 2026. Something wrong or missing? Report it on the NBIX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z