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NBI-827104 · ACT-709478

Small molecule · Antagonist of T-type calcium channel · developed by NEUROCRINE BIOSCIENCES

Phase 2 Most advanced trial (none active)

NBIX Developer

1 Registered trials

What is NBI-827104?

NBI-827104 is a T-type calcium channel blocker studied in epileptic encephalopathy and continuous spike and wave during sleep.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: ACT-709478
Drug type: Small molecule
Targets: T-type calcium channel
Mechanism: Antagonist of T-type calcium channel
Therapy area: Neurology
Developer: NEUROCRINE BIOSCIENCES (NBIX)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2
UNII: 3Z7U1U8Z9E

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05301894	Phase 2	Epileptic Encephalopathy	Terminated	NBIX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Continuous Spike and Wave During SleepEpileptic Encephalopathy

More from NEUROCRINE BIOSCIENCES

Crinecerfont FDA approved Valbenazine FDA approved Chronocort Phase 3 DITEST Phase 1 Luvadaxistat Phase 2 NBI-1065845 Phase 3 NBI-1065890 Phase 2 NBI-1070770 Phase 2 NBI-1117567 Phase 2 NBI-1117568 Phase 3 NBI-1117570 Phase 2 NBI-921352 Phase 2

Sources

ClinicalTrials.gov NCT05301894

Updated Oct 3, 2026. Something wrong or missing? Report it on the NBIX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z