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Naloxone · Evzio, Narcan

Small molecule · Antagonist of mu-opioid receptor (OPRM1) · developed by Kaleo

Approved FDA, Apr 2014
3 Registered trials

What is Naloxone?

Naloxone is an opioid antagonist that competes with opioids for their receptor sites, reversing respiratory depression, sedation and hypotension. It is studied in heroin dependence and opioid use disorder, including buprenorphine/naloxone combinations.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
Evzio, Narcan, Rivive
Drug type
Small molecule
Targets
mu-opioid receptor (OPRM1), kappa-opioid receptor (OPRK1) (secondary target), delta-opioid receptor (OPRD1) (secondary target)
Mechanism
Antagonist of mu-opioid receptor (OPRM1)
Pathways
opioid receptor competitive antagonism, reversal of opioid-induced respiratory depression and sedation
Therapy area
Psychiatry
Developer
Kaleo Inc
In trials of
ALKS, AVIR, BCYC
FDA status
Approved as Evzio, Narcan, Rivive (April 3, 2014), NDA205787 · FDA label

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT05644587 Phase 4 Opioid Use Disorder Terminated BCYC
NCT03711318 Phase 3 Heroin Dependence Terminated ALKS
NCT07314346 Phase 1 Healthy Volunteer Study Recruiting AVIR

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Healthy Volunteer StudyHeroin DependenceOpioid AbuseOpioid DependenceOpioid MisuseOpioid UseOpioid Use Disorder

Other drugs acting on OPRM1

Methadone FDA approved Morphine FDA approved Nalbuphine FDA approved Naltrexone FDA approved Oxycodone FDA approved PF614 Phase 3

Sources

Updated Oct 11, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.