Morphine · Morphine Sulfate, Oramorph Sr

What is Morphine?

Morphine is a full opioid agonist that binds primarily to mu-opioid receptors and secondarily to delta and kappa receptors. It is studied in acute pain associated with myocardial infarction and unstable angina.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Morphine Sulfate, Oramorph Sr

Drug type

Small molecule

Targets

mu-opioid receptor (OPRM1), delta-opioid receptor (OPRD1) (secondary target), kappa-opioid receptor (OPRK1) (secondary target)

Mechanism

Agonist of mu-opioid receptor (OPRM1)

Pathways

analgesia, CNS depression, respiratory depression

Therapy area

Cardiovascular

Developer

Xanodyne Pharms Inc

In trials of

BLRX, COLL

FDA status

Approved as Morphine Sulfate, Oramorph Sr (August 15, 1991), NDA019977 · FDA label

✅ FDA-approved uses

• Management of pain severe enough to require an opioid analgesic (Morphine Sulfate)

From the indications section of the FDA label (version of Aug 31, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Acute PainNon-ST-segment Elevation Myocardial InfarctionST-segment Elevation Myocardial InfarctionUnstable AnginaUnstable Angina PectorisVA Drug Interactions

Other drugs acting on OPRM1

Sources

• FDA label (DailyMed)
• FDA label Morphine Sulfate (2026-08-31), indications
• NCI Thesaurus
• ClinicalTrials.gov NCT02939235
• ClinicalTrials.gov NCT02939248

Updated Oct 3, 2026.