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GI-6301

Vaccine · Immune activation, directed at brachyury (TBXT) · developed by ImmunityBio

Phase 1/2 Most advanced trial (none active)

IBRX Developer

1 Registered trials

What is GI-6301?

GI-6301 is a cancer vaccine composed of heat-killed, recombinant Saccharomyces cerevisiae genetically modified to express brachyury. It elicits CD4+ and CD8+ T-lymphocyte-mediated immune responses against brachyury-expressing tumor cells. It is studied in head and neck squamous cell carcinoma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Vaccine
Targets: brachyury (TBXT) (antigen)
Mechanism: Immune activation, directed at brachyury (TBXT)
Pathways: immune_activation, CD4+ T-cell response, CD8+ T-cell response
Therapy area: Oncology
Developer: ImmunityBio, Inc. (IBRX)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2
UNII: B0L24T8TB7

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT03169764	Phase 1/2	Head and Neck Squamous Cell Carcinoma	Withdrawn	IBRX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Head and Neck Squamous Cell Carcinoma

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Sources

NCI Thesaurus

Updated Oct 3, 2026. Something wrong or missing? Report it on the IBRX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z