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ETBX-051

Vaccine (Adenoviral vector) · Immune activation, directed at brachyury (TBXT) · developed by ImmunityBio

Phase 1/2 Most advanced trial (none active)

IBRX Developer

1 Registered trials

What is ETBX-051?

ETBX-051 is a replication-defective adenovirus serotype 5 vaccine encoding the tumor-associated antigen brachyury. It induces cytotoxic T-lymphocyte responses against brachyury-expressing tumor cells. The vaccine is studied in head and neck squamous cell carcinoma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Vaccine (Adenoviral vector)
Targets: brachyury (TBXT) (antigen)
Mechanism: Immune activation, directed at brachyury (TBXT)
Pathways: immune activation, CTL-mediated cytotoxicity
Therapy area: Oncology
Developer: ImmunityBio, Inc. (IBRX)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2
UNII: BPG11IF0HW

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT03169764	Phase 1/2	Head and Neck Squamous Cell Carcinoma	Withdrawn	IBRX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Head and Neck Squamous Cell Carcinoma

More from ImmunityBio

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Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the IBRX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z