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Alpha-1

Plasma-derived product · Protein replacement · developed by Grifols Therapeutics LLC

Phase 3 Most advanced trial

GRFS Developer

1 Registered trials

What is Alpha-1?

Alpha-1 15% is a subcutaneous human alpha-1 proteinase inhibitor preparation containing alpha-1 antitrypsin, the protein deficient in alpha-1 antitrypsin deficiency. It is being studied in patients with alpha-1 antitrypsin deficiency.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Plasma-derived product
Mechanism: Protein replacement
Therapy area: Respiratory
Developer: Grifols Therapeutics LLC (GRFS)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 3

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07555483	Phase 3	Alpha 1 Antitrypsin Deficiency	Recruiting	GRFS

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Alpha 1 Antitrypsin Deficiency

More from Grifols Therapeutics LLC

albumin human, USP FDA approved Antithrombin III FDA approved factor VIII / von Willebrand factor FDA approved C19-IG Phase 3 Fibrin Sealant Grifols Phase 3 GRF312 Phase 2 Human Plasma-Derived Fibrinogen Concentrate Phase 1/2 IVIG-PEG Phase 3 plasma-derived FVIII/VWF concentrate Phase 4

Sources

ClinicalTrials.gov NCT07555483

Updated Oct 11, 2026. Something wrong or missing? Report it on the GRFS page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z