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Antithrombin III · Thrombate Iii, ORG 10849

Plasma-derived product · Protein replacement · developed by Grifols Therapeutics LLC

Approved FDA, Dec 1991
GRFS Developer
1 Registered trials

What is Antithrombin III?

Antithrombin III is a human plasma-derived protein, encoded by the SERPINC1 gene, that negatively regulates serine proteinase activity during blood coagulation. It is studied in antithrombin III deficiency and in COVID-19.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
Thrombate Iii, ORG 10849, Thrombate III
Drug type
Plasma-derived product
Mechanism
Protein replacement
Pathways
blood coagulation, negative regulation of serine proteinase activity
Therapy area
Hematology, Infectious disease
Developer
Grifols Therapeutics LLC (GRFS)
FDA status
Approved as Thrombate Iii (December 30, 1991), BLA103196
UNII
T0LTO7L82X

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT04899232 Phase 2 Antithrombin III Deficiency Terminated GRFS

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Antithrombin III DeficiencyCovid19

More from Grifols Therapeutics LLC

albumin human, USP FDA approved factor VIII / von Willebrand factor FDA approved Alpha-1 Phase 3 C19-IG Phase 3 Fibrin Sealant Grifols Phase 3 GRF312 Phase 2 Human Plasma-Derived Fibrinogen Concentrate Phase 1/2 IVIG-PEG Phase 3 plasma-derived FVIII/VWF concentrate Phase 4

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the GRFS page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.