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factor VIII / von Willebrand factor · Alphanate

Plasma-derived product · Protein replacement · developed by Grifols Biologicals LLC

Approved FDA, Aug 1978

GRFS Developer

3 Registered trials

What is factor VIII / von Willebrand factor?

Alphanate is a human plasma-derived concentrate containing antihemophilic factor (factor VIII) and von Willebrand factor. It is studied in von Willebrand disease and congenital hemophilia A, with dosing measured in VWF:RCo and FVIII:C units.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: Alphanate, Alphanate SD/HT
Drug type: Plasma-derived product
Mechanism: Protein replacement
Therapy area: Hematology
Developer: Grifols Biologicals LLC (GRFS)
FDA status: Approved as Alphanate (August 15, 1978), BLA102475

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT00555555	Phase 4	Von Willebrand Disease	Terminated	GRFS
NCT03095287	Phase 2	Hemophilia A, Congenital	Terminated	GRFS
NCT01051076	N/A	Severe Hemophilia A	Completed	GRFS

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Hemophilia A, CongenitalVon Willebrand Disease

More from Grifols Biologicals LLC

albumin human, USP FDA approved Antithrombin III FDA approved Alpha-1 Phase 3 C19-IG Phase 3 Fibrin Sealant Grifols Phase 3 GRF312 Phase 2 Human Plasma-Derived Fibrinogen Concentrate Phase 1/2 IVIG-PEG Phase 3 plasma-derived FVIII/VWF concentrate Phase 4

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the GRFS page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z