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ALN-AGT01 RVR

Oligonucleotide (siRNA) · Gene silencing: angiotensinogen (AGT) · developed by ALNYLAM PHARMACEUTICALS

Phase 2 Most advanced trial

ALNY Developer

1 Registered trials

What is ALN-AGT01 RVR?

ALN-AGT01 RVR is a subcutaneously administered small interfering RNA drug. It is studied in hypertension.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Oligonucleotide (siRNA)
Targets: angiotensinogen (AGT)
Mechanism: Gene silencing: angiotensinogen (AGT)
Therapy area: Cardiovascular
Developer: ALNYLAM PHARMACEUTICALS (ALNY)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07553442	Phase 2	Hypertension	Recruiting	ALNY

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Hypertension

Other drugs acting on AGT

IONIS-AGT-LRx Phase 2 Zilebesiran Phase 3

More from ALNYLAM PHARMACEUTICALS

Givosiran FDA approved Lumasiran FDA approved Patisiran FDA approved Vutrisiran FDA approved ALN-2232 Phase 1/2 ALN-4285 Phase 1 ALN-4324 Phase 2 ALN-4915 Phase 1 ALN-5288 Phase 1 ALN-6222 Phase 1 ALN-6400 Phase 1/2 ALN-BCAT Phase 1

Sources

ClinicalTrials.gov NCT07553442

Updated Oct 11, 2026. Something wrong or missing? Report it on the ALNY page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z