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ALN-BCAT

Oligonucleotide (siRNA) · Gene silencing: beta-catenin (CTNNB1) · developed by ALNYLAM PHARMACEUTICALS

Phase 1 Most advanced trial

ALNY Developer

1 Registered trials

What is ALN-BCAT?

ALN-BCAT is a lipid nanoparticle-encapsulated small interfering RNA that targets beta-catenin mRNA, reducing beta-catenin translation and expression in tumor cells. It is being studied in hepatocellular carcinoma, including advanced and metastatic disease.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Oligonucleotide (siRNA)
Targets: beta-catenin (CTNNB1)
Mechanism: Gene silencing: beta-catenin (CTNNB1)
Pathways: Wnt/beta-catenin signaling, Wnt target gene transcription
Therapy area: Oncology
Developer: ALNYLAM PHARMACEUTICALS (ALNY)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT06600321	Phase 1	Advanced Hepatocellular Carcinoma	Recruiting	ALNY

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Advanced Hepatocellular CarcinomaMetastatic Hepatocellular Carcinoma

More from ALNYLAM PHARMACEUTICALS

Givosiran FDA approved Lumasiran FDA approved Patisiran FDA approved Vutrisiran FDA approved ALN-2232 Phase 1/2 ALN-4285 Phase 1 ALN-4324 Phase 2 ALN-4915 Phase 1 ALN-5288 Phase 1 ALN-6222 Phase 1 ALN-6400 Phase 1/2 ALN-AGT01 RVR Phase 2

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the ALNY page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z