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IONIS-AGT-LRx · ISIS 757456

Oligonucleotide (Antisense oligonucleotide) · Gene silencing: angiotensinogen (AGT) · developed by IONIS PHARMACEUTICALS

Phase 2 Most advanced trial (none active)

IONS Developer

1 Registered trials

What is IONIS-AGT-LRx?

IONIS-AGT-LRx is an antisense oligonucleotide that reduces angiotensinogen (AGT) production. It is administered by subcutaneous injection and is being studied in hypertension.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: ISIS 757456
Drug type: Oligonucleotide (Antisense oligonucleotide)
Targets: angiotensinogen (AGT)
Mechanism: Gene silencing: angiotensinogen (AGT)
Therapy area: Cardiovascular
Developer: IONIS PHARMACEUTICALS (IONS)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT04714320	Phase 2	Hypertension	Completed	IONS

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Hypertension

Other drugs acting on AGT

ALN-AGT01 RVR Phase 2 Zilebesiran Phase 3

More from IONIS PHARMACEUTICALS

Donidalorsen FDA approved Olezarsen FDA approved Zilganersen FDA approved BIIB094 Phase 1 ION224 Phase 2 ION269 Phase 1 ION337 Phase 1/2 ION356 Phase 1 ION363 Phase 3 ION440 Phase 1/2 ION464 Phase 1 ION717 Phase 1/2

Sources

ClinicalTrials.gov NCT04714320

Updated Oct 3, 2026. Something wrong or missing? Report it on the IONS page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z