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WVE-120102 · BMTR-5149, WV-2603

Oligonucleotide (Antisense oligonucleotide) · Gene silencing: huntingtin (HTT) · developed by Wave Life Sciences

Phase 1/2 Most advanced trial (none active)

WVE Developer

1 Registered trials

What is WVE-120102?

WVE-120102 is a stereopure antisense oligonucleotide that reduces huntingtin protein production. It is studied in Huntington's disease.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: BMTR-5149, WV-2603
Drug type: Oligonucleotide (Antisense oligonucleotide)
Targets: huntingtin (HTT)
Mechanism: Gene silencing: huntingtin (HTT)
Therapy area: Neurology
Developer: Wave Life Sciences (WVE)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2
UNII: RV6BTB6SX2

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT03225846	Phase 1/2	Huntington's Disease	Terminated	WVE

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Huntington's Disease

Other drugs acting on HTT

ALN-HTT02 Phase 1 WVE-003 Phase 1/2 WVE-120101 Phase 1/2

More from Wave Life Sciences

WVE-003 Phase 1/2 WVE-004 Phase 1/2 WVE-006 Phase 1/2 WVE-007 Phase 1/2 WVE-120101 Phase 1/2 WVE-210201 Phase 2/3 WVE-N531 Phase 1/2

Sources

ClinicalTrials.gov NCT03225846

Updated Oct 3, 2026. Something wrong or missing? Report it on the WVE page.

Follow WVE, the company behind WVE-120102

See WVE's upcoming FDA decisions, trial readouts, cash runway and dilution risk, updated every day from SEC, FDA and ClinicalTrials.gov filings.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z