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Tirasemtiv · CK-2017357

Small molecule · developed by Cytokinetics

Phase 3 Most advanced trial (none active)

CYTK Developer

5 Registered trials

What is Tirasemtiv?

Tirasemtiv is an investigational small-molecule drug studied in Intermittent Claudication, Peripheral Artery Disease, Myasthenia Gravis.

At a glance

Also known as: CK-2017357
Drug type: Small molecule
Therapy area: Neurology
Developer: Cytokinetics (CYTK)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 3
UNII: G8WSM7R635

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT02936635	Phase 3	Amyotrophic Lateral Sclerosis (ALS)	Completed	CYTK
NCT01709149	Phase 2	Amyotrophic Lateral Sclerosis	Completed	CYTK
NCT01378676	Phase 2	Amyotrophic Lateral Sclerosis	Completed	CYTK
NCT01268280	Phase 2	Myasthenia Gravis	Terminated	CYTK
NCT01131013	Phase 2	Intermittent Claudication	Completed	CYTK

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Amyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis (ALS)Intermittent ClaudicationMyasthenia GravisPeripheral Artery Disease

More from Cytokinetics

Aficamten FDA approved AMG 423 Phase 1 CK-3828136 Phase 1 Omecamtiv Mecarbil Phase 3 Reldesemtiv Phase 3 SB-743921 Phase 1/2 Ulacamten Phase 2

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the CYTK page.

Follow CYTK, the company behind Tirasemtiv

See CYTK's upcoming FDA decisions, trial readouts, cash runway and dilution risk, updated every day from SEC, FDA and ClinicalTrials.gov filings.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z