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SB-743921

Small molecule · Inhibitor of kinesin spindle protein (KSP) (KIF11) · developed by Cytokinetics

Phase 1/2 Most advanced trial (none active)

CYTK Developer

1 Registered trials

What is SB-743921?

SB-743921 is a synthetic small molecule that selectively inhibits kinesin spindle protein (KSP), blocking mitotic spindle assembly and interrupting cell division. It induces cell cycle arrest and apoptosis in proliferating cells and is studied in Non-Hodgkin's lymphoma and Hodgkin's disease.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Small molecule
Targets: kinesin spindle protein (KSP) (KIF11)
Mechanism: Inhibitor of kinesin spindle protein (KSP) (KIF11)
Pathways: mitotic spindle assembly, cell cycle arrest, apoptosis
Therapy area: Oncology
Developer: Cytokinetics (CYTK)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2
UNII: 24DSZ1VN92

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT00343564	Phase 1/2	Non-Hodgkin's Lymphoma	Completed	CYTK

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Hodgkin's DiseaseNon-Hodgkin's Lymphoma

Other drugs acting on KIF11

Ispinesib Phase 1

More from Cytokinetics

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Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the CYTK page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z