Tenofovir · Biktarvy, Descovy

What is Tenofovir?

Tenofovir alafenamide (TAF) is a nucleoside reverse transcriptase inhibitor that blocks HIV-1 replication.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Biktarvy, Descovy

Drug type

Small molecule

Targets

HIV-1 reverse transcriptase

Mechanism

Inhibitor of HIV-1 reverse transcriptase

Pathways

reverse transcription inhibition

Therapy area

Infectious disease

Developer

Gilead Sciences, Inc.

In trials of

ARWR, IBO

FDA status

Approved as Biktarvy, Descovy, NDA208215 · FDA label

✅ FDA-approved uses

• HIV-1 infection treatment (Descovy)
• HIV-1 pre-exposure prophylaxis (Descovy)
• HIV-1 infection treatment (Biktarvy)

From the indications section of the FDA label (version of Jul 7, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Hepatitis BHIV

Sources

• FDA label (DailyMed)
• FDA label Descovy (2026-07-07), indications
• FDA label Biktarvy (2024-04-30), indications
• NCI Thesaurus
• ClinicalTrials.gov NCT02738008

Updated Oct 3, 2026.