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Pb-PSV359

Radiopharmaceutical · Cytotoxic, directed at fibroblast activation protein (FAP) (FAP) · developed by Perspective Therapeutics

Phase 1/2 Most advanced trial
CATX Developer
1 Registered trials

What is Pb-PSV359?

Pb-PSV359 is a lead-labeled radiopharmaceutical that targets fibroblast activation protein (FAP), which is expressed on FAP-positive cancers. The 203Pb form is given for single-photon emission computed tomography imaging, and the 212Pb form is given by intravenous infusion for treatment of FAP-expressing cancers, including pancreatic, gastric, esophageal, colorectal, ovarian, head and neck cancers, sarcoma and mesothelioma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type
Radiopharmaceutical
Targets
fibroblast activation protein (FAP) (FAP)
Mechanism
Cytotoxic, directed at fibroblast activation protein (FAP) (FAP)
Therapy area
Oncology
Developer
Perspective Therapeutics (CATX)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 1/2

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT06710756 Phase 1/2 Pancreatic Ductal Adenocarcinoma Recruiting CATX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Colorectal CancerEsophageal CancerGastric CancerHead and Neck CancerMesotheliomaOvarian CancerPancreatic Ductal AdenocarcinomaSarcoma

Other drugs acting on FAP

More from Perspective Therapeutics

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the CATX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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