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Lead Pb 203-VMT01

Radiopharmaceutical · Acts on Melanocortin-1 receptor (MC1R) · developed by Perspective Therapeutics

Phase 1/2 Most advanced trial
CATX Developer
1 Registered trials

What is Lead Pb 203-VMT01?

Lead Pb 203-VMT01 is a radioconjugate in which the melanocyte-stimulating hormone receptor-targeting peptide VMT01 carries the radioisotope lead Pb 203. The peptide binds MC1R, a G protein-coupled receptor upregulated on metastatic melanoma cells, allowing those cells to be detected by SPECT/CT imaging. It is studied in recurrent and metastatic melanoma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
[203Pb]VMT01
Drug type
Radiopharmaceutical
Targets
Melanocortin-1 receptor (MC1R)
Mechanism
Acts on Melanocortin-1 receptor (MC1R)
Therapy area
Oncology
Developer
Perspective Therapeutics (CATX)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 1/2

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT05655312 Phase 1/2 Recurrent Melanoma (Skin) Recruiting CATX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Melanoma Stage IIIMelanoma Stage IVMetastatic MelanomaRecurrent Melanoma (Skin)

Other drugs acting on MC1R

More from Perspective Therapeutics

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the CATX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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