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Paclitaxel Vitamin E-Based · S-8184

Small molecule · Inhibitor of tubulin · developed by Achieve Life Sciences

Phase 2 Most advanced trial (none active)
ACHV Developer
1 Registered trials

What is Paclitaxel Vitamin E-Based?

Paclitaxel Vitamin E-Based is a cremophor-free, vitamin E-based emulsion formulation of paclitaxel. Paclitaxel binds tubulin and inhibits microtubule disassembly, blocking cell division, and the emulsion component inhibits the P-glycoprotein efflux pump. It is studied in colorectal adenocarcinoma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
S-8184
Drug type
Small molecule
Targets
tubulin, apoptosis regulator Bcl-2 (BCL2) (secondary target), P-glycoprotein (ABCB1 drug efflux pump) (ABCB1) (secondary target)
Mechanism
Inhibitor of tubulin
Pathways
microtubule disassembly, cell division, apoptosis
Therapy area
Oncology
Developer
Achieve Life Sciences (ACHV)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 2

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT00034190 Phase 2 Colorectal Adenocarcinoma Completed ACHV

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Colorectal Adenocarcinoma

More from Achieve Life Sciences

Apatorsen Phase 2 Custirsen Phase 3 Cytisinicline Phase 3 Tenifatecan Phase 1

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the ACHV page.

Follow ACHV, the company behind Paclitaxel Vitamin E-Based

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.