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Cytisinicline · NSC-407282

Small molecule · Agonist of nicotinic acetylcholine receptor · developed by Achieve Life Sciences

Phase 3 Most advanced trial

ACHV Developer

2 Registered trials

What is Cytisinicline?

Cytisinicline is a small-molecule nicotinic acetylcholine receptor agonist being studied for smoking and vaping cessation. It is formulated as a film-coated tablet containing 1.5 mg cytisine.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: NSC-407282, cytisine
Drug type: Small molecule
Targets: nicotinic acetylcholine receptor
Mechanism: Agonist of nicotinic acetylcholine receptor
Therapy area: Psychiatry
Developer: Achieve Life Sciences (ACHV)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 3
UNII: 53S5U404NU

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07392125	Phase 3	Vaping Cessation	Not yet recruiting	ACHV
NCT03709823	Phase 2	Smoking Cessation	Completed	ACHV

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Vaping CessationSmoking Cessation

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Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the ACHV page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z