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Nucresiran

Oligonucleotide (siRNA) · Gene silencing: transthyretin (TTR) · developed by Alnylam Pharmaceuticals

Phase 3 Most advanced trial

ALNY Developer

1 Registered trials

What is Nucresiran?

Nucresiran (ALN-TTRSC04) is a subcutaneously administered small interfering RNA that targets transthyretin (TTR) messenger RNA to lower production of the TTR protein. It is being studied in hereditary transthyretin-mediated amyloidosis with polyneuropathy.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: ALN-TTRSC04
Drug type: Oligonucleotide (siRNA)
Targets: transthyretin (TTR)
Mechanism: Gene silencing: transthyretin (TTR)
Therapy area: Neurology
Developer: Alnylam Pharmaceuticals (ALNY)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 3
UNII: MCT9H26JQY

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07223203	Phase 3	Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy	Recruiting	ALNY

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

hATTR-PN

Other drugs acting on TTR

Inotersen FDA approved Patisiran FDA approved Vutrisiran FDA approved ALN-TTRSC04 Phase 1 NTLA-2001 Phase 3

More from Alnylam Pharmaceuticals

Givosiran FDA approved Lumasiran FDA approved Patisiran FDA approved Vutrisiran FDA approved ALN-2232 Phase 1/2 ALN-4285 Phase 1 ALN-4324 Phase 2 ALN-4915 Phase 1 ALN-5288 Phase 1 ALN-6222 Phase 1 ALN-6400 Phase 1/2 ALN-AGT01 RVR Phase 2

Sources

ClinicalTrials.gov NCT07223203

Updated Oct 11, 2026. Something wrong or missing? Report it on the ALNY page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z