Dashboard PDUFA PDUFA History Dilution Watch Downside Radar Missed Milestones Earnings Big Movers Blog

🎤 Upcoming Biotech Conferences

Loading conferences...

Free to browse, no account needed Follow the companies behind these drugs with free AI briefings, catalyst countdowns and dilution alerts.

Start 7-day free trial → Log in

MORF-057

Small molecule · Inhibitor of integrin alpha4beta7 · developed by Eli Lilly and Company

Phase 2 Most advanced trial

LLY Developer

1 Registered trials

What is MORF-057?

MORF-057 (zotemtegrast) is an orally administered small molecule designed to selectively inhibit integrin α4β7. It is being studied in inflammatory bowel diseases, including Crohn's disease.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: zotemtegrast
Drug type: Small molecule
Targets: integrin alpha4beta7
Mechanism: Inhibitor of integrin alpha4beta7
Therapy area: Gastroenterology
Developer: Eli Lilly and Company (LLY)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT06226883	Phase 2	Inflammatory Bowel Diseases	Recruiting	LLY

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Crohn's DiseaseInflammatory Bowel Diseases

More from Eli Lilly and Company

Abemaciclib FDA approved Baricitinib FDA approved Donanemab FDA approved Dulaglutide FDA approved Imlunestrant FDA approved Lebrikizumab FDA approved Mirikizumab FDA approved Orforglipron FDA approved Pirtobrutinib FDA approved Selpercatinib FDA approved Tirzepatide FDA approved Brenipatide Phase 3

Sources

ClinicalTrials.gov NCT06226883

Updated Oct 11, 2026. Something wrong or missing? Report it on the LLY page.

Follow LLY, the company behind MORF-057

See LLY's upcoming FDA decisions, trial readouts, cash runway and dilution risk, updated every day from SEC, FDA and ClinicalTrials.gov filings.

LLY catalysts and pipeline →

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z