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Mifepristone · Korlym, NSC-759862

Small molecule · Antagonist of progesterone receptor (PGR) and glucocorticoid receptor (NR3C1) · developed by Danco Labs Llc

Approved FDA, Sep 2000

3 Registered trials

What is Mifepristone?

Mifepristone is a selective antagonist of the progesterone receptor and glucocorticoid receptor.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: Korlym, NSC-759862, RU 38486, RU 486
Drug type: Small molecule
Targets: progesterone receptor (PGR), glucocorticoid receptor (NR3C1)
Mechanism: Antagonist of progesterone receptor (PGR) and glucocorticoid receptor (NR3C1)
Therapy area: Endocrine
Developer: Danco Labs Llc
In trials of: CORT
FDA status: Approved as Korlym (September 28, 2000), NDA020687 · FDA label
UNII: 320T6RNW1F

✅ FDA-approved uses

Hyperglycemia secondary to hypercortisolism in endogenous Cushing's syndrome with type 2 diabetes mellitus or glucose intolerance
Hyperglycemia secondary to hypercortisolism in endogenous Cushing's syndrome with type 2 diabetes mellitus or glucose intolerance

From the indications section of the FDA label (version of Sep 25, 2025). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05772169	Phase 4	Hypercortisolism	Completed	CORT
NCT06689254	Phase 2	Treatment-resistant PTSD	Recruiting	CORT
NCT06099769	Phase 2	Metastatic Breast Cancer	Recruiting	CORT

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Metastatic Breast CancerTreatment-resistant PTSDDiabetes Mellitus, Type 2Hypercortisolism

Other drugs acting on PGR / NR3C1

Beclomethasone Dipropionate FDA approved Budesonide FDA approved Ethinyl Estradiol/Levonorgestrel FDA approved IDP-118 FDA approved Infacort FDA approved Methylprednisolone FDA approved Mometasone FDA approved Mometasone Furoate FDA approved Relacorilant FDA approved Segesterone Acetate and Ethinyl Estradiol FDA approved Chronocort Phase 3 Exicorilant Phase 1/2

Sources

Updated Oct 3, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z