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Iodine I 125 Iopofosine · CLR 125

Radiopharmaceutical · Cytotoxic · developed by Cellectar Biosciences

Phase 1 Most advanced trial
CLRB Developer
1 Registered trials

What is Iodine I 125 Iopofosine?

Iodine I 125 iopofosine is a radioconjugate of iopofosine, a phospholipid ether analog labeled with the Auger-emitting isotope iodine I 125. It selectively accumulates in tumor cells that have increased membrane lipid rafts, enters the cells and travels to the nucleus, where it causes DNA double-strand breaks. It is being studied in breast cancer.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
CLR 125
Drug type
Radiopharmaceutical
Mechanism
Cytotoxic
Pathways
lipid raft accumulation, DNA double-strand breaks
Therapy area
Oncology
Developer
Cellectar Biosciences, Inc. (CLRB)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT07311993 Phase 1 Breast Cancer Recruiting CLRB

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Breast Cancer

More from Cellectar Biosciences

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the CLRB page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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