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Iodine I 124 Iopofosine · I-124

Radiopharmaceutical · developed by Cellectar Biosciences

Phase 2 Most advanced trial (none active)
CLRB Developer
2 Registered trials

What is Iodine I 124 Iopofosine?

Iodine I 124 iopofosine is a radioconjugate of the radioisotope iodine I 124 attached to the alkylphospholipid ether analog iopofosine, intended for positron emission tomography imaging. It is taken up and retained by tumor cells, which accumulate it through lipid rafts and metabolize it poorly because of lower phospholipase-D activity. It is studied in multiple solid tumors and glioblastoma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
I-124, 124I-NM404
Drug type
Radiopharmaceutical
Therapy area
Oncology
Developer
Cellectar Biosciences, Inc. (CLRB)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 2

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT01898273 Phase 2 Glioblastoma Terminated CLRB
NCT01662284 N/A Triple Negative Breast, Prostate, Colorectal, Gastric, Ovarian, Pancreatic… Terminated CLRB

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Glioblastoma

More from Cellectar Biosciences

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the CLRB page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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