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Diranersen · ISIS 814907, BIIB-080

Oligonucleotide (Antisense oligonucleotide) · Gene silencing · developed by BIOGEN

Phase 2 Most advanced trial

BIIB Developer

1 Registered trials

What is Diranersen?

Diranersen (ISIS 814907, BIIB080) is an antisense oligonucleotide studied in mild cognitive impairment and Alzheimer's disease dementia.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: ISIS 814907, BIIB-080
Drug type: Oligonucleotide (Antisense oligonucleotide)
Mechanism: Gene silencing
Therapy area: Neurology
Developer: BIOGEN (BIIB)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2
UNII: 96J3L33PWD

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05399888	Phase 2	Mild Cognitive Impairment Due to Alzheimer's Disease	Active not recruiting	BIIB

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Alzheimer's Disease DementiaMild Cognitive Impairment Due to Alzheimer's Disease

More from BIOGEN

Dimethyl Fumarate FDA approved Diroximel Fumarate FDA approved Interferon Beta-1A FDA approved Natalizumab FDA approved Nusinersen FDA approved Omaveloxolone FDA approved Tofersen FDA approved Zuranolone FDA approved BIIB115 Phase 1 BIIB122 Phase 3 BIIB144 Phase 1 BIIB147 Phase 1/2

Sources

ClinicalTrials.gov NCT05399888

Updated Oct 3, 2026. Something wrong or missing? Report it on the BIIB page.

Follow BIIB, the company behind Diranersen

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z