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Dasminapant · APG-1387

Small molecule · Antagonist of XIAP, c-IAP1 (BIRC2) and c-IAP2 (BIRC3) · developed by Ascentage Pharma Group

Phase 1/2 Most advanced trial (none active)

AAPG Developer

1 Registered trials

What is Dasminapant?

Dasminapant is a SMAC mimetic that inhibits inhibitor of apoptosis proteins (IAPs) including XIAP, c-IAP1, and c-IAP2. By blocking IAPs, it restores apoptotic signaling and promotes cancer cell death. It is being studied in advanced pancreatic cancer.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: APG-1387
Drug type: Small molecule
Targets: XIAP, c-IAP1 (BIRC2), c-IAP2 (BIRC3)
Mechanism: Antagonist of XIAP, c-IAP1 (BIRC2) and c-IAP2 (BIRC3)
Pathways: apoptosis
Therapy area: Oncology
Developer: Ascentage Pharma Group Inc. (AAPG)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2
UNII: E53VN70K2X

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT04643405	Phase 1/2	Advanced Pancreatic Cancer	Terminated	AAPG

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Advanced Pancreatic Cancer

Other drugs acting on XIAP / BIRC2 / BIRC3

Birinapant Phase 1/2 GDC-0917 Phase 1

More from Ascentage Pharma Group

Alrizomadlin Phase 1/2 APG-2449 Phase 1 APG-3288 Phase 1 APG-5918 Phase 1 Lisaftoclax Phase 3 Olverembatinib Phase 3 Pelcitoclax Phase 1/2

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the AAPG page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z