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APG-5918

Small molecule · Inhibitor of EED · developed by Ascentage Pharma Group

Phase 1 Most advanced trial

AAPG Developer

1 Registered trials

What is APG-5918?

APG-5918 is an orally bioavailable small molecule allosteric inhibitor of the EED protein, a component of polycomb repressive complex 2 (PRC2). It binds EED to prevent H3K27 methylation and alter gene expression in cancer cells. The drug is studied in anemia and EZH2-mutated cancers.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Small molecule
Targets: EED, EZH2 (binding partner it blocks)
Mechanism: Inhibitor of EED
Pathways: H3K27 methylation, gene expression, PRC2 activity
Therapy area: Hematology
Developer: Ascentage Pharma Group Inc. (AAPG)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05773586	Phase 1	Anemia	Recruiting	AAPG

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Anemia

Other drugs acting on EED

Rinzimetostat Phase 3

More from Ascentage Pharma Group

Alrizomadlin Phase 1/2 APG-2449 Phase 1 APG-3288 Phase 1 Dasminapant Phase 1/2 Lisaftoclax Phase 3 Olverembatinib Phase 3 Pelcitoclax Phase 1/2

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the AAPG page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z