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CERC-006 · AEVI-006, ASP-7486

Small molecule · Inhibitor of mTOR · developed by Avalo Therapeutics

Phase 1 Most advanced trial (none active)
AVTX Developer
1 Registered trials

What is CERC-006?

CERC-006 is an orally bioavailable mTOR kinase inhibitor that binds and inhibits both the raptor-mTOR (TORC1) and rictor-mTOR (TORC2) complexes. It acts on the PI3K/Akt/mTOR signaling pathway, which is upregulated in some tumors. It is studied in lymphatic malformation.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
AEVI-006, ASP-7486
Drug type
Small molecule
Targets
mTOR
Mechanism
Inhibitor of mTOR
Pathways
PI3K/Akt/mTOR signaling, apoptosis, tumor cell proliferation
Therapy area
Hematology
Developer
Avalo Therapeutics, Inc. (AVTX)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 1
UNII
25MKH1SZ0M

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT04994002 Phase 1 Lymphatic Malformation Withdrawn AVTX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Lymphatic Malformation

Other drugs acting on MTOR

Gedatolisib FDA approved Sirolimus FDA approved CC-115 Phase 2 Encapsulated Rapamycin Phase 2 Samotolisib Phase 2

More from Avalo Therapeutics

AVTX-002 Phase 2 AVTX-009 Phase 2 Camoteskimab Phase 1 CERC-301 Phase 2 FP01 Phase 2

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the AVTX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.