Small molecule · Inhibitor of viral RNA-dependent RNA polymerase · developed by Atea Pharmaceuticals
Bemnifosbuvir is an orally bioavailable purine nucleotide prodrug that is metabolized into an active form which inhibits viral RNA-dependent RNA polymerase, terminating viral RNA transcription and replication. It is studied in COVID-19 and chronic hepatitis C virus infection.
Summary written with AI from the sources listed at the end of this page.
| Trial | Phase | Condition | Status | Sponsor |
|---|---|---|---|---|
| NCT05629962 | Phase 3 | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2 Infection) | Completed | AVIR |
| NCT04889040 | Phase 3 | COVID-19 | Terminated | AVIR |
| NCT05904470 | Phase 2 | Chronic Hepatitis C Virus | Completed | AVIR |
| NCT04396106 | Phase 2 | COVID-19 | Terminated | AVIR |
| NCT07272889 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT06911320 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT06921941 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT06204679 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT05731843 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT05618314 | Phase 1 | Healthy Volunteer | Completed | AVIR |
| NCT05256732 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT05154123 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT05137626 | Phase 1 | Healthy Volunteers Study | Completed | AVIR |
| NCT05004415 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT04865445 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT04849299 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
| NCT04711187 | Phase 1 | Healthy Volunteer Study | Completed | AVIR |
Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.
Chronic Hepatitis C VirusCOVID-19HCVHealthy VolunteerHealthy Volunteer StudyHealthy Volunteers StudyHepatic CirrhosisHepatic ImpairmentHepatitis CHepatitis C, ChronicRenal Impairment
Updated Oct 11, 2026. Something wrong or missing? Report it on the AVIR page.
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