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Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted γδ T Cells

Cell therapy (CAR-T) · Kills target cells, directed at NKG2D ligands · developed by CytoMed Therapeutics Pte

Phase 1 Most advanced trial
GDTC Developer
1 Registered trials

What is Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted γδ T Cells?

CTM-N2D is an allogeneic cell therapy made from healthy donor gamma delta T cells expanded ex vivo and engineered by mRNA electroporation with chimeric antigen receptors targeting NKG2D ligands. The cells are infused into cancer patients, with the aim of killing NKG2D ligand-expressing cancer cells. It is studied in cancer, malignancy and relapsed or refractory cancer.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type
Cell therapy (CAR-T)
Targets
NKG2D ligands (antigen)
Mechanism
Kills target cells, directed at NKG2D ligands
Therapy area
Oncology
Developer
CytoMed Therapeutics Pte Ltd (GDTC)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT05302037 Phase 1 Cancer Recruiting GDTC

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

CancerMalignancyRefractory CancerRelapsed Cancer

More from CytoMed Therapeutics Pte

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the GDTC page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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