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Adoptive Cell Transfer of NKG2DL-targetting Chimeric Antigen Receptor-grafted Gamma Delta T cell

Cell therapy (CAR-T) · Kills target cells, directed at NKG2D ligands · developed by CytoMed Therapeutics Pte

Phase 1 Most advanced trial (none active)
GDTC Developer
1 Registered trials

What is Adoptive Cell Transfer of NKG2DL-targetting Chimeric Antigen Receptor-grafted Gamma Delta T cell?

Adoptive cell transfer of haploidentical or allogeneic gamma delta T cells grafted with a chimeric antigen receptor targeting NKG2D ligands (CTM-N2D). The engineered cells are designed to recognize and kill NKG2D ligand-expressing tumor cells. It is studied in colorectal cancer, triple negative breast cancer, sarcoma, nasopharyngeal carcinoma, prostate cancer and gastric cancer.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type
Cell therapy (CAR-T)
Targets
NKG2D ligands (antigen)
Mechanism
Kills target cells, directed at NKG2D ligands
Therapy area
Oncology
Developer
CytoMed Therapeutics Pte Ltd (GDTC)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT04107142 Phase 1 Colorectal Cancer Unknown GDTC

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Colorectal CancerGastric CancerNasopharyngeal CarcinomaProstate CancerSarcomaTriple Negative Breast Cancer

More from CytoMed Therapeutics Pte

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the GDTC page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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