Company guidance, FDA catalysts, dilution risk and cash runway, built from SEC, FDA and ClinicalTrials.gov filings and updated every day.
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Quoted word for word from the company's press releases filed with the SEC. Timing is the company's own guidance, not a BioRadar estimate.
| Drug | Indication | Most advanced trial | Status |
|---|---|---|---|
| Epinephrine FDA approved Aug 2024 · Neffy |
Allergic Reactions | Phase 4 · NCT06834165 | Recruiting |
| Albuterol MDI 90 mcg/inh | Asthma | Phase 2 · NCT05363670 | Completed |
| ARS-1 | Urticaria | Phase 2 · NCT05496465 | Completed |
| ARS-1 without URTI | Upper Respiratory Tract Infection | Phase 1 · NCT04930900 | Completed |
Source: ClinicalTrials.gov trials sponsored by the company, one row per candidate at its most advanced registered trial. FDA approvals: Drugs@FDA. Wrong or missing drug? Report it
SPRY holds $143.8M in cash and short-term investments (as of Jun 30, 2026) and burns about $52.9M/quarter from operations, an estimated runway of 8.2 months at that rate (BioRadar estimate, not company guidance).
Dilution pressure: 55 · Elevated
Recent financing filings on SEC EDGAR:
Source: SEC EDGAR (XBRL cash flow and financing filings). Dilution Watch: every company ranked → · Get an alert when SPRY files for a raise →
| Holder | Type | Shares | % of shares | As of |
|---|---|---|---|---|
| Sarina Tanimoto CHIEF MEDICAL OFFICER, 10% owner · +1.12M options |
Insider | 11,353,141 | 11.42% | 2025-08-19 |
| Richard E Lowenthal PRESIDENT AND CEO, Director, 10% owner · +1.12M options |
Insider | 11,303,141 | 11.37% | 2025-08-21 |
| RA Capital Management, L.P. | Institution (13G, 5%+) | 10,940,977 | 11.00% | 2025-09-29 |
| James E Flynn 10% owner |
Insider | 9,774,508 | 9.83% | 2025-06-27 |
| Orbimed Advisors LLC. | Institution (13F) | 8,288,510 | 8.33% | 2026-06-30 |
| Rubric Capital Management LP | Institution (13G, 5%+) | 8,000,000 | 8.04% | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution (13G, 5%+) | 7,610,217 | 7.65% | 2025-07-30 |
| BlackRock, Inc. | Institution (13G, 5%+) | 5,218,264 | 5.25% | 2026-06-30 |
| Pratik Shah Director · +60,000 options |
Insider | 4,474,554 | 4.50% | 2025-11-12 |
| Tyro Capital Management LLC | Institution (13F) | 4,459,337 | 4.48% | 2026-06-30 |
| Aberdeen Group plc | Institution (13F) | 4,170,629 | 4.19% | 2026-06-30 |
| SR One Capital Management, LP | Institution (13F) | 4,012,903 | 4.04% | 2026-06-30 |
Share count 99,447,343 (latest 10-Q/10-K). Insiders: each officer's, director's and 10% owner's latest Form 3, 4 or 5, direct and indirect shares; options are not counted. 5%+ holders: latest Schedule 13D or 13G of each holder above 5%. Institutions: the total held by all 13F filers (Yahoo Finance); the table lists the largest (13F quarter ending 2026-06-30). Sources have different dates, so the split is approximate. Source: SEC EDGAR.
| Trade date | Insider | Transaction | Shares | Price | Owned after |
|---|---|---|---|---|---|
| 2026-09-01 filed 2026-09-02 |
Smith Margaret Ekins |
Option award (A) | 1,001,738 | – | – |
| 2026-07-01 filed 2026-07-02 |
Casale Donn |
Option award (A) | 898,456 | – | – |
| 2026-06-24 filed 2026-06-26 |
SCHNEIDER PHILLIP M |
Option award (A) | 30,000 | – | – |
| 2026-06-24 filed 2026-06-26 |
SAUNDERS BRENT L |
Option award (A) | 30,000 | – | – |
| 2026-06-24 filed 2026-06-26 |
RA Capital Healthcare Fund L |
Option award (A) | 30,000 | – | – |
Only open-market purchases (P) and sales (S) are trading decisions. Awards (A), option exercises (M) and tax withholding (F) are compensation mechanics. Source: SEC Form 4.
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