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Zirconium Zr 89 Girentuximab

Radiopharmaceutical · Acts on carbonic anhydrase IX (CA9) · developed by Telix Pharmaceuticals Pty

Phase 3 Most advanced trial
TLX Developer
3 Registered trials

What is Zirconium Zr 89 Girentuximab?

Zirconium Zr 89 girentuximab is a radioimmunoconjugate comprising a chimeric monoclonal antibody labeled with zirconium-89 for positron emission tomography imaging. The antibody binds carbonic anhydrase IX (CAIX), a hypoxia-inducible transmembrane protein overexpressed on renal cell carcinoma and other tumors. It enables imaging and quantification of CAIX-expressing tumor cells.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
89Zr-TLX250 PET/CT, 89Zr-Girentuximab, 89Zr-DFO-TFP-girentuximab, 89Zr-TLX250
Drug type
Radiopharmaceutical
Targets
carbonic anhydrase IX (CA9)
Mechanism
Acts on carbonic anhydrase IX (CA9)
Therapy area
Oncology
Developer
Telix Pharmaceuticals Pty Limited (TLX)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 3

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT06750419 Phase 3 Clear Cell Renal Cell Carcinoma Recruiting TLX
NCT07077083 Phase 2 Clear Cell Renal Cell Carcinoma (ccRCC) Not yet recruiting TLX
NCT06447103 Phase 2 Clear Cell Renal Cell Carcinoma Recruiting TLX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

ccRCCClear Cell Renal Cell CarcinomaClear Cell Renal Cell Carcinoma (ccRCC)Sarcomatoid Renal Cell CarcinomaStage II Renal Cell CancerStage III Renal Cell CancerStage IV Renal Cell Cancer

More from Telix Pharmaceuticals Pty

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the TLX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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