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Zilovertamab Vedotin · MK-2140, VLS-101

Antibody-drug conjugate · Cytotoxic, directed at ROR1 · developed by Merck &

Phase 1/2 Most advanced trial

MRK Developer

1 Registered trials

What is Zilovertamab Vedotin?

Zilovertamab vedotin is an antibody-drug conjugate composed of a humanized IgG1 monoclonal antibody against ROR1 conjugated to monomethyl auristatin E (MMAE). Upon binding to ROR1 on tumor cells and internalization, MMAE disrupts microtubule polymerization, causing G2/M phase arrest and apoptosis. It is studied in urothelial carcinoma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: MK-2140, VLS-101
Drug type: Antibody-drug conjugate
Targets: ROR1, tubulin (secondary target)
Mechanism: Cytotoxic, directed at ROR1
Pathways: microtubule disruption, G2/M phase arrest, apoptosis
Therapy area: Oncology
Developer: Merck & Co. (MRK)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2
UNII: IZY9ZSI6FI

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05562830	Phase 1/2	Urothelial Carcinoma	Recruiting	MRK

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Urothelial Carcinoma

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Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the MRK page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z