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Xanomeline · Cobenfy, LY-246708

Small molecule · Agonist of M1 muscarinic acetylcholine receptor (CHRM1) and M4 muscarinic acetylcholine receptor (CHRM4) · developed by E.R. Squibb & Sons, L.L.C.

Approved FDA

BMY Developer

1 Registered trials

What is Xanomeline?

Xanomeline is a muscarinic acetylcholine receptor agonist that acts on M1 and M4 receptors in the central nervous system. It is combined with trospium chloride, a peripheral muscarinic antagonist, to reduce peripheral side effects.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: Cobenfy, LY-246708
Drug type: Small molecule
Targets: M1 muscarinic acetylcholine receptor (CHRM1), M4 muscarinic acetylcholine receptor (CHRM4)
Mechanism: Agonist of M1 muscarinic acetylcholine receptor (CHRM1) and M4 muscarinic acetylcholine receptor (CHRM4)
Therapy area: Psychiatry
Developer: E.R. Squibb & Sons, L.L.C. (BMY)
FDA status: Approved as Cobenfy, NDA216158 · FDA label
UNII: 9ORI6L73CJ

✅ FDA-approved uses

Schizophrenia

From the indications section of the FDA label (version of Jan 16, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07686263	Phase 3	Schizophrenia	Recruiting	BMY

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Schizophrenia

Other drugs acting on CHRM1 / CHRM4

Xanomeline And Trospium FDA approved KarX-EC Phase 3

More from E.R. Squibb & Sons, L.L.C.

Apixaban FDA approved Belatacept FDA approved Deucravacitinib FDA approved Ipilimumab FDA approved Lisocabtagene Maraleucel FDA approved Luspatercept FDA approved Mavacamten FDA approved Nab-paclitaxel FDA approved Nivolumab FDA approved Ozanimod FDA approved Relatlimab FDA approved Repotrectinib FDA approved

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the BMY page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z