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Trichostatin A · NSC-311042, VTR-297

Small molecule · Inhibitor of histone deacetylases · developed by Vanda Pharmaceuticals

Phase 2 Most advanced trial

VNDA Developer

1 Registered trials

What is Trichostatin A?

Trichostatin A is a natural small-molecule histone deacetylase inhibitor isolated from Streptomyces bacteria. It reversibly inhibits histone deacetylases, promoting histone hyperacetylation and selective gene transcription. The drug is studied in onychomycosis of the toenail.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: NSC-311042, VTR-297
Drug type: Small molecule
Targets: histone deacetylases
Mechanism: Inhibitor of histone deacetylases
Pathways: chromatin remodeling, histone acetylation, gene transcription
Therapy area: Dermatology
Developer: Vanda Pharmaceuticals (VNDA)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2
UNII: 3X2S926L3Z

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07065773	Phase 2	Onychomycosis of Toenail	Active not recruiting	VNDA

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Onychomycosis of Toenail

More from Vanda Pharmaceuticals

Iloperidone FDA approved Milsaperidone FDA approved Ponesimod FDA approved Tasimelteon FDA approved Tradipitant FDA approved VCA-894A Phase 1/2 VQW-765 Phase 3 VSJ-110 Phase 2

Sources

NCI Thesaurus

Updated Oct 3, 2026. Something wrong or missing? Report it on the VNDA page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z