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TransCon CNP · Yuviwel, ACP-015

Peptide · Agonist of natriuretic peptide receptor-B (NPR2) · developed by Ascendis

Approved FDA, Feb 2026

ASND Developer

1 Registered trials

What is TransCon CNP?

TransCon CNP (navepegritide, ACP-015) is a C-type natriuretic peptide (CNP) analog released from a prodrug form. It binds natriuretic peptide receptor-B, raising cGMP and protein kinase G signaling, which inhibits the MAPK pathway and counters overactive FGFR3 signaling. It is studied in achondroplasia.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: Yuviwel, ACP-015
Drug type: Peptide
Targets: natriuretic peptide receptor-B (NPR2)
Mechanism: Agonist of natriuretic peptide receptor-B (NPR2)
Pathways: cGMP/protein kinase G signaling, MAPK signaling inhibition, endochondral ossification and chondrocyte proliferation
Therapy area: Musculoskeletal
Developer: Ascendis (ASND)
FDA status: Approved as Yuviwel (February 27, 2026), NDA219164 · FDA label
UNII: Y3BH8M899D

✅ FDA-approved uses

Achondroplasia

From the indications section of the FDA label (version of Mar 25, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05929807	Phase 2/3	Achondroplasia	Enrolling by invitation	ASND

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Achondroplasia

Other drugs acting on NPR2

Navepegritide FDA approved Cenderitide Phase 2

More from Ascendis

Lonapegsomatropin FDA approved Navepegritide FDA approved Palopegteriparatide FDA approved ACP-001 Phase 2 Resiquimod Hydrogel-based Phase 1/2 TransCon hGH Phase 3 TransCon Treprostinil Phase 1

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the ASND page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z