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Segesterone Acetate and Ethinyl Estradiol · Annovera

Small molecule · Agonist of Estrogen receptor alpha (ESR1) and Progesterone receptor (PGR) · developed by Mayne Pharma

Approved FDA, Aug 2018
1 Registered trials

What is Segesterone Acetate and Ethinyl Estradiol?

Segesterone acetate and ethinyl estradiol is a combination oral contraceptive containing a progestin and estrogen. It prevents pregnancy primarily by suppressing ovulation.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
Annovera
Drug type
Small molecule
Targets
Estrogen receptor alpha (ESR1), Progesterone receptor (PGR)
Mechanism
Agonist of Estrogen receptor alpha (ESR1) and Progesterone receptor (PGR)
Pathways
ovulation suppression, androgen signaling
Therapy area
Dermatology, Women's health
Developer
Mayne Pharma
In trials of
TXMD
FDA status
Approved as Annovera (August 10, 2018), NDA209627 · FDA label

✅ FDA-approved uses

From the indications section of the FDA label (version of Oct 4, 2023). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT04272008 Phase 1 Contraception Completed TXMD

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Contraception

Other drugs acting on ESR1 / PGR

Camizestrant FDA approved Ethinyl Estradiol/Levonorgestrel FDA approved Imlunestrant FDA approved Mifepristone FDA approved Tamoxifen FDA approved Vepdegestrant FDA approved Giredestrant Phase 1/2 Onapristone Phase 1/2 Zuclomiphene Phase 2

Sources

Updated Oct 3, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.